Helicobacter pylori (HP) ke baktheria e phelang ka mpeng 'me e khomarela mucosa ea gastric le libaka tsa intercellular, e bakang ho ruruha.Tšoaetso ea HP ke e 'ngoe ea mafu a atileng haholo a baktheria, a tšoaetsang batho ba libilione lefatšeng ka bophara.Ke tsona sesosa se ka sehloohong sa liso le gastritis (ho ruruha ha lesela la mala).

Tšoaetso e phahameng ho bana le ho kopana ha malapa ke litšobotsi tsa bohlokoa tsa tšoaetso ea HP, 'me phetisetso ea malapa e ka' na ea e-ba tsela e ka sehloohong tšoaetso ea HP ke sesosa se ka sehloohong sa lefu la gastritis le sa foleng, seso sa peptic, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, le kankere ea mala.Ka 1994, Mokhatlo oa Lefatše oa Bophelo / Mokhatlo oa Machaba oa Lipatlisiso ka Kankere (WHO/IARC) o ile oa khetha Helicobacter pylori e le sehlopha sa I carcinogen.

Gastric mucosa - sehlomo sa 'mele oa mpa

Tlas'a maemo a tloaelehileng, lerako la mpa le na le letoto la mekhoa e phethahetseng ea ho itšireletsa (ho hlahisoa ha gastric acid le protease, tšireletso ea li-mucus tse sa tsitsang le tse qhibilihang, boikoetliso ba kamehla, joalo-joalo), bo ka hanang tlhaselo ea likokoana-hloko tse likete. tse kenang ka molomo.

HP e na le flagella e ikemetseng le sebopeho se ikhethang sa helical, se sa bapaleng feela karolo ea ho tiisa nakong ea kolone ea baktheria, empa hape e ka ba selikalikoe 'me ea theha morphology ea ho itšireletsa libakeng tse thata.Ka nako e ts'oanang, Helicobacter pylori e ka hlahisa chefo e sa tšoaneng, e etsang qeto ea hore Helicobacter pylori e ka feta ka lera la lero la gastric ka matla a eona 'me e hanela gastric acid le lintho tse ling tse sa thabiseng, e leng eona feela likokoana-hloko tse ka phelang ka mpeng ea motho. .

Pathogenesis ea Helicobacter pylori

1. E matla

Liphuputso li bontšitse hore Helicobacter pylori e na le matla a matla a ho tsamaea sebakeng sa viscous, 'me flagella e hlokahala hore libaktheria li sese ho ea ho lera le sireletsang la mucus holim'a mucosa ea gastric.

2. Endotoxin e amanang le protheine A (CagA) le chefo ea vacuolar (VacA)

Cytotoxin-associated gene A (CagA) protheine e patiloeng ke HP e ka tsosa karabelo ea sebaka sa ho ruruha.Tšoaetso ea CagA-positive Helicobacter pylori le eona e ka eketsa haholo kotsi ea ho tšoaroa ke lefu la atrophic gastritis, mala a mala le kankere ea mala.

Vacuolating cytotoxin A (VacA) ke ntlha e 'ngoe ea bohlokoa ka ho fetisisa ea pathogenic ea Helicobacter pylori, e ka kenang mitochondria ho laola mosebetsi oa organelles.

3. Flagellin

Liprotheine tse peli tsa flagellin, FlaA le FlaB, li etsa likarolo tse kholo tsa likhoele tsa flagellar.Liphetoho ho flagellin glycosylation li ama motility ea khatello.Ha boemo ba FlaA protein glycosylation bo ntse bo eketseha, bokhoni ba ho falla le boima ba bokolone bo ile ba eketseha.

4. Urease

Urease e hlahisa NH3 le CO2 ka hydrolyzing urea, e fokotsang asiti ea ka mpeng le ho phahamisa pH ea lisele tse haufi.Ho phaella moo, urease e kenya letsoho likarabong tsa ho ruruha 'me e khothalletsa ho khomarela ka ho sebelisana le li-receptor tsa CD74 ka lisele tsa gastric epithelial.

5. Protheine ea mocheso oa mocheso HSP60/GroEL

Helicobacter pylori e monya letoto la liprotheine tse bolokiloeng haholo tsa mocheso oa mocheso, tseo poleloana ea Hsp60 le urease ho E. coli e eketsang haholo ts'ebetso ea urease, e lumellang pathogen ho ikamahanya le maemo le ho phela sebakeng se tletseng bora sa tikoloho ea mpa ea motho.

6. Protheine e amanang le Hook 2 homolog FliD

FliD ke protheine ea sebopeho e sireletsang ntlha ea flagella 'me e khona ho kenya flagellin khafetsa ho hōlisa likhoele tsa flagellar.FliD e boetse e sebelisoa e le molek'hule e khomarelang, e hlokomelang limolek'hule tsa glycosaminoglycan tsa lisele tse amohelang.Ho batho ba tšoaelitsoeng, li-anti-flid ke matšoao a tšoaetso 'me li ka sebelisoa bakeng sa tlhahlobo ea serological.

Mekhoa ea Teko:

1. Teko ea mantle: Teko ea antigen ea setulo ke teko e sa hlaseleng H. pylori.Ts'ebetso e bolokehile, e bonolo ebile e potlakile, 'me ha e hloke tsamaiso ea molomo ea li-reagents leha e le life.

2. Ho fumanoa ha Serum antibody: Ha tšoaetso ea Helicobacter pylori e hlaha 'meleng,' mele oa motho o tla ba le li-antibodies tsa Helicobacter pylori maling ka lebaka la karabelo ea 'mele ea ho itšireletsa mafung.Ka ho hula mali ho hlahloba bongata ba li-antibodies tsa Helicobacter pylori, e ka bonahatsa hore na ho na le Helicobacter pylori 'meleng.tšoaetso ea baktheria.

3. Teko ea phefumoloho: Ona ke mokhoa o tsebahalang haholo oa tlhahlobo hajoale.Urea ea molomo e nang le 13C kapa 14C, le tlhahlobo ea phefumoloho ea carbon dioxide e nang le 13C kapa 14C ka mor'a nako e itseng, hobane haeba ho na le Helicobacter pylori, urea e tla fumanoa ke urea ea eona e khethehileng.Li-enzyme li senyeha ho ba ammonia le carbon dioxide, e ntšoang matšoafong ka mali.

4. Endoscopy: e lumella ka hloko tlhokomelo e haufi-ufi ea likarolo tsa gastric mucosal tse kang bofubelu, ho ruruha, liphetoho tsa nodular, joalo-joalo;endoscopy ha e loketse bakuli ba nang le mathata a tebileng kapa li-contraindications le litšenyehelo tse eketsehileng (anesthesia, forceps) ).

Lihlahisoa tse amanang le bioantibody tsa H.pylorilikhothaletso:

H. Pylori Antigen Rapid Test Kit (Lateral Chromatography)

H. Pylori Antibody Rapid Test Kit (Lateral Chromatography)