Khothaletsa Mokhoa oa Nts'etsopele ea Lithethefatsi
Lintlha tse akaretsang
Bioantibody ea boemo ba pele le e maemong a holimo ka ho fetisisa e etselitsoe ho sebetsana le litlhoko tsa bohlokoa tsa bongaka tse sa fihlelleheng ka nts'etsopele ea kalafo ea protheine ea mono le bi-specific, li-antibody drug conjugates le li-macrophage stimulating agents bakeng sa bakuli lefatšeng ka bophara.
Histori
Ho sibolloa ho hoholo ha thekenoloji ea monoclonal antibody (mAb) ke Kohler le Milstein ka 1975 ho fane ka monyetla oa ho theha masole a 'mele e le sehlopha sa kalafo (Kohler & Milstein, 1975).Li-antibodies tsa monoclonal (mAbs) ke e 'ngoe ea liforomo tse sebelisoang ka ho fetesisa tsa lithethefatsi bakeng sa mafu a tšoaetsanoang kapa kalafo ea mofets'e hobane li khetha li lebisitse ho likokoana-hloko, lisele tse tšoaetsanoang, lisele tsa mofetše, esita le lisele tsa 'mele.Ka tsela ena, ba buisana ka ho felisoa ha limolek'hule le lisele tse nang le litla-morao tse fokolang ho feta mekhoa e meng ea phekolo.Haholo-holo, li-mAbs tsa kalafo ea mofetše li ka lemoha liprotheine tse holim'a sele ho lisele tse shebiloeng ebe li bolaea lisele tse lebisitsoeng ho tsona ka mekhoa e mengata.
Humanization e fokotsa haholo matla a ho itšireletsa mafung a 'mele ho batho, e leng se etsang hore tsamaiso e sa foleng e khonehe.Khatelo-pele e joalo ea theknoloji ea li-antibody e bakile ho phatloha ho hoholo ho nts'etsopele ea li-mAbs tsa kalafo lilemong tse leshome tse fetileng.Letoto la li-antibody tse tsoang ho li-antibody, tse kenyeletsang liprotheine tsa Fc-fusion, antibody-drug conjugates (ADCs), immunocytokines (antibody-cytokine fusions), le li-antibody-enzyme fusions, le tsona lia ntlafatsoa le ho rekisoa e le phekolo e ncha.
Liphello tsa lithethefatsi
Bakeng sa bakuli, lithethefatsi tse lebisitsoeng tse ncha li bolela litla-morao tse fokolang, lipetlele tse fokolang, bophelo bo ntlafetseng, tlhahiso e eketsehileng, 'me habohlokoa, bophelo bo atolositsoeng.Empa nts'etsopele ea lithethefatsi ke ts'ebetso e telele, e rarahaneng.
Referense
Kohler G, Milstein C. Meetlo e tsoelang pele ea lisele tse kopantsoeng tse ntšang li-antibody tse boletsoeng esale pele.Tlhaho.1975;256:495–497.doi: 10.1038/256495a0
Ecker DM, Jones SD, Levine HL.Therapeutic monoclonal antibody market.MABS.2015;7:9–14.doi: 10.4161/19420862.2015.989042.
Peters C, Brown S. Antibody-drug conjugates as novel anti-cancer chemotherapeutics.Biosci Rep. 2015;35(4):e00225.E phatlalalitsoe 2015 Jul 14. E fumaneha ho https://pubmed.ncbi.nlm.nih.gov/26182432/.E fihletsoe ka Phupu 2020.
Reichert, JM, le Valge-Archer, VE (2007).Mekhoa ea nts'etsopele ea kalafo ea mofetše oa monoclonal antibody.Nat Rev Drug Discov 6, 349-356.
Lazar, GA, Dang, W., Karki, S., Vafa, O., Peng, JS, Hyun, L., Chan, C., Chung, HS, Eivazi, A., Yoder, SC, et al.(2006).Mefuta e fapaneng ea antibody Fc e nang le ts'ebetso e ntlafalitsoeng.PNAS 103, 4005–4010.
