Anti- PIVKA -II Antibody, Mouse Monoclonal
Lintlha tse akaretsang
Protheine e Hlahetsoeng ke Vitamin K Absence kapa Antagonist-II (PIVKA-II), e tsejoang hape e le Des-γ-carboxy-prothrombin (DCP), ke mofuta o sa tloaelehang oa prothrombin.Ka tloaelo, masala a prothrombin a 10 glutamic acid (Glu) sebakeng sa γ-carboxyglutamic acid (Gla) sebakeng sa 6, 7, 14, 16, 19, 20,25, 26, 29 le 32 ke γ-carboxylated ho Gla by vithamine. -K e itšetlehileng ka γ- glutamyl carboxylase sebeteng ebe e kenngoa ka har'a plasma.Ho bakuli ba nang le hepatocellular carcinoma (HCC), γ-carboxylation ea prothrombin e senyeha e le hore PIVKA-II e thehoe sebakeng sa prothrombin.PIVKA-II e nkoa e le biomarker e sebetsang hantle bakeng sa HCC.
Thepa
| Keletso ea para | CLIA (Tlhapa-Tshireletso): 1E5 ~ 1D6 1E5 ~ 1E6 |
| Bohloeki | >95%, e khethoa ke SDS-PAGE |
| Tlhahiso ea Buffer | 20 mM PB, 150 mM NaCl, 0.1% Proclin 300, pH7.4 |
| Polokelo | E boloke tlas'a maemo a nyopa ho -20 ℃ ho -80 ℃ ha e amoheloa.Bakeng sa polokelo ea nako e telele, ka kopo aliquot 'me u e boloke.Qoba ho ba le serame khafetsa le ho qhibiliha. |
Tlhahlobo ea Papiso
Lintlha tsa Odara
| Lebitso la Sehlahiswa | Katse.Che | ID ea Clone |
| PIVKA-Ⅱ | AB0009-1 | 1F4 |
| AB0009-2 | 1E5 | |
| AB0009-3 | 1D6 | |
| AB0009-4 | 1E6 |
Tlhokomeliso: Li-bioantibody li ka ikamahanya le maemo ho latela tlhoko ea hau.
Litlhaloso
1.Matsueda K , Yamamoto H , Yoshida Y , et al.Hepatoid carcinoma ea manyeme a hlahisang protheine e bakoang ke ho ba sieo ha vithamine K kapa mohanyetsi oa II (PIVKA-II) le α-fetoprotein (AFP) [J].Journal of Gastroenterology, 2006, 41(10):1011-1019.
2.Viggiani, Valentina, Palombi, 等.Protheine e bakoang ke ho ba sieo ha vithamine K kapa mohanyetsi-II (PIVKA-II) e eketsehile ka ho khetheha ho bakuli ba Italy ba hepatocellular carcinoma.[J].Scandinavian Journal of Gastroenterology, 2016.
3.Simundic AM .Litlhahiso tse sebetsang bakeng sa tlhahlobo ea lipalo-palo le tlhahiso ea data ho Biochemia Medica Journal[J].Biochemia Medica, 2012, 22(1).
4.Tartaglione S , Pecorella I , Zarrillo SR , et al.Protheine e Hlahetsoeng ke Vitamin K Absence II (PIVKA-II) e le serological biomarker e ka bang teng mofetšeng oa pancreatic: thuto ea sefofane[J].Biochemia Medica, 2019, 29(2).
