Anti- human CHI3L1 Antibody, motho Monoclonal
Lintlha tsa sehlahisoa
Lintlha tse akaretsang
Chitinase-3-like protheine 1 (CHI3L1) ke glycoprotein e tlamang heparin e patiloeng eo polelo ea eona e amanang le ho falla ha lisele tsa vascular smooth muscle.CHI3L1 e hlahisoa ka maemo a holimo litsong tsa postconfluent nodular VSMC le maemong a tlase litsong tse ntseng li ata.CHI3L1 ke lectin e thibelitsoeng ka lisele, e tlamang chitin le setho sa lelapa la glycosyl hydrolase 18. Ho fapana le li-marker tse ling tse ngata tsa monocyto / macrophage, polelo ea eona ha e eo monocyte 'me e susumetsoa ka matla nakong ea morao-rao ea phapang ea macrophage ea batho.Maemo a phahameng a CHI3L1 a amahanngoa le mathata a bonts'ang phetoho e ntseng e eketseha ea lithane tse amanang, joalo ka rheum atoid, ramatiki, osteoarthritis, scleroderma le cirrhosis ea sebete, empa e hlahisoa ka lefufuru ho tsoa ho bafani ba khale kapa bakuli ba nang le lefu la masapo a manonyeletso.CHI3L1 e hlahisoa ka mokhoa o sa tloaelehang ho hippocampus ea batho ba nang le schizophrenia 'me e ka' na ea ameha karabelong ea lisele ho liketsahalo tse fapa-fapaneng tsa tikoloho tse tlalehoang ho eketsa kotsi ea schizophrenia.
Thepa
| Keletso ea para | CLIA (Tlhapa-Tshireletso): 2E4-2 ~ 1G11-14 13F3-1 ~ 1G11-14 |
| Bohloeki | >95%, e khethoa ke SDS-PAGE |
| Tlhahiso ea Buffer | PBS, pH7.4 |
| Polokelo | E boloke tlas'a maemo a nyopa ho -20 ℃ ho -80 ℃ ha e amoheloa. Bakeng sa polokelo ea nako e telele, ka kopo aliquot 'me u e boloke.Qoba ho ba le serame khafetsa le ho qhibiliha. |
Tlhahlobo ea Papiso
| Bioantibody | nyeoe e fumanoeng ke tleliniki | Kakaretso | |
| ntle | E mpe | ||
| ntle | 46 | 3 | 49 |
| E mpe | 4 | 97 | 101 |
| Kakaretso | 50 | 100 | 150 |
| evaluation index | kutloelo-bohloko | tse khethehileng | nepahalo |
| 92% | 97% | 95% | |
Lintlha tsa Odara
| Lebitso la Sehlahiswa | Katse.Che | ID ea Clone |
| CHI3L1 | AB0031-1 | 1G11-14 |
| AB0031-2 | 2E4-2 | |
| AB0031-3 | 3A12-1 | |
| AB0031-4 | 13F3-1 |
Tlhokomeliso: Li-bioantibody li ka ikamahanya le maemo ho latela tlhoko ea hau.
Litlhaloso
1.Kyrgios I , Galli-Tsinopoulou A , Stylianou C , et al.Maemo a phahameng a potoloho a serum acute-phase protein YKL-40 (chitinase 3-like protein 1) ke letšoao la botenya le ho hanyetsa insulin ho bana ba pele ho nako [J].Metabolism-clinical & Experimental, 2012, 61 (4): 562-568.
2.Yu-Huan M , Li-Ming T , Jian-Ying LI , et al.Tlhahlobo mabapi le tšebeliso ea serum chitinase-3-joaloka protheine 1, alpha-fetoprotein le ferritin ho lemoha ho hlahloba lefu la kankere ea sebete [J].Meriana e Sebetsang ea Thibelo, 2018.
