Anti-human MMP-3 Antibody, Mouse Monoclonal
Lintlha tsa sehlahisoa
Lintlha tse akaretsang
Matrix metallopeptidase 3 (e khutsufalitsoeng joalo ka MMP3) e boetse e tsejoa e le stromelysin 1 le progelatinase.MMP3 ke setho sa lelapa la matrix metalloproteinase (MMP) leo litho tsa lona li kenyang letsoho ho senyeha ha matrix a extracellular ka mekhoa e tloaelehileng ea 'mele, e kang tsoelo-pele ea embryonic, ho ikatisa, ho tsosolosoa ha lisele, le mekhoa ea maloetse ho akarelletsa le ramatiki le metastasis.E le endopeptidase e itšetlehileng ka zinki e patiloeng, MMP3 e etsa mesebetsi ea eona haholo-holo matrix a extracellular.Protheine ena e sebelisoa ke li-inhibitors tse peli tse kholo tsa endogenous: alpha2-macroglobulin le li-tissue inhibitors tsa metalloprotease (TIMPs).MMP3 e bapala karolo ea mantlha ho nyenyefatseng mefuta ea collagen ea II, III, IV, IX, le X, proteoglycans, fibronectin, laminin, le elastin.Hape, MMP3 e ka kenya tšebetsong li-MMP tse ling tse kang MMP1, MMP7, le MMP9, ea etsa hore MMP3 e be ea bohlokoa tokisong e hokahantsoeng ea lisele.Ho senyeha ha li-MMP ho kenyelelitsoe maloetseng a mangata a kenyeletsang ramatiki, liso tse sa foleng, encephalomyelitis, le kankere.Li-synthetic kapa li-inhibitors tsa tlhaho tsa MMP li fella ka ho thibela metastasis, ha taolo e phahameng ea li-MMP e lebisitse ho hlaselong e matla ea lisele tsa mofetše.
Thepa
| Keletso ea para | CLIA (Tlhapa-Tshireletso): 11G11-6 ~ 8A3-9 11G11-6 ~ 5B9-4 |
| Bohloeki | >95%, e khethoa ke SDS-PAGE |
| Tlhahiso ea Buffer | PBS, pH7.4. |
| Polokelo | E boloke tlas'a maemo a nyopa ho -20 ℃ ho -80 ℃ ha e amoheloa. Khothalletsa ho aliquot protheine ka bongata bo nyane bakeng sa polokelo e nepahetseng. |
Papiso ea Tlholisano
Lintlha tsa Odara
| Lebitso la Sehlahiswa | Katse.Che | ID ea Clone |
| MMP-3 | AB0025-1 | 11G11-6 |
| AB0025-2 | 8A3-9 | |
| AB0025-3 | 5B9-4 |
Tlhokomeliso: Li-bioantibody li ka ikamahanya le maemo ho latela tlhoko ea hau.
Litlhaloso
1.Yamanaka H , Matsuda Y , Tanaka M , et al.Serum matrix metalloproteinase 3 e le selelekela sa tekanyo ea ho senyeha ha manonyeletso nakong ea likhoeli tse tšeletseng ka mor'a tekanyo, ho bakuli ba nang le ramatiki ea pele ea ramatiki[J].Ramatiki le Rheumatism, 2000, 43(4):852–858.
2.Hattori Y , Kida D , Kaneko A .Maemo a tloaelehileng a serum metalloproteinase-3 a ka sebelisoa ho bolela esale pele phokolo ea bongaka le tšebetso e tloaelehileng ea 'mele ho bakuli ba nang le ramatiki ea ramatiki [J].Clinical Rheumatology, 2018.
